Osteogenesis Imperfecta (OI)

Osteogenesis imperfecta (OI) is a group of genetic diseases of collagen in which the bones are formed improperly. This improper bone formation makes the bones weak and prone to breaking. Multiple bone fractures are common. There eight forms of osteogenesis imperfecta, type I through type VIII. Type I is the mildest form of osteogenesis imperfecta and type II is the most severe. Type I OI is characterized by bone fractures during childhood and adolescence. Type II OI symptoms include an abnormally small rib cage and underdeveloped lungs.Symptoms for all types of osteogenesis imperfecta (OI) include: frequent bone fractures,blue sclerae, short stature, hearing loss, and respiratory problems.