Canavan Disease

Canavan disease is a gene-linked neurological disorder in which the white matter of the brain is degenerated into spongy tissues. This disease is caused by mutations in the enzyme gene called aspartacylase. Canavan is a type of leukodystrophy. Individuals with this disease may suffer from paralysis, blindness, hearing loss, mental retardation, abnormal muscle tone, and an abnormally large head.